Shimadzu-TOF-TOF Mass Spectrometer (Model:MALDI-7090TM )

• MultiPlex^TM: a flexible multi-user walk-up system offering unparalleled efficiency and versatility
• A source design like no other: For sensitivity and ease of use
• Hyper-MS^2TM: Combining core technologies patented and exclusive to Shimadzu for ultimate performance in MS/MS acquisition

Designed for reliability the MultiPlex offers unmatched flexibility in both the high-throughput and multi-user environment.

• Wide Bore ion Optics: Consisting of unique wide-bore extraction optics, the MALDI-7090 ion optics are designed to maximize ion transmission and minimize source contamination over time.
• Ultra fast Laser: Shimadzu’s proprietary solid-state UV laser, designed specifically for the MALDI-7090, delivers true 2kHz acquisition speed in all modes. The added benefits of variable beam focus and long lifetime maximize reliability and broad-range applicability.
• HD sample viewing: The MALDI-7090 incorporates the latest state-of-the -art camera technology to deliver high-quality full HD color images of the sample with 10µm viewing resolution, software-controlled variable focus and long-life LED illumination.
• TrueClean^TM: Optimal performance of the MALDI-7090 source is maintained using TrueClean – a novel and fully automated source cleaning process. TrueClean cleans the source electrodes by redirecting the UV laser onto their surface and desorbing any contaminant material. This method is highly efficient and does not require source removal or venting.

• High resolution ion gating for accurate precursor ion selection
• Unparalleled MS/MS resolution achieved using patented axial spatial distribution focusing: ASDF^TM.
• High and low energy fragmentation maximizing the amount of information extracted from a sample

Compounds of similar nominal mass may produce MS/MS spectra that contain fragment ions from several precursors if not gated correctly. However, the high-resolution ion gate in the MALDI-7090 allows the individual gating of species close in nominal mass thus producing distinct fragment ion spectra.

With ASDF, the MALDI-7090 can achieve mass resolution of 10,000 FHWM – unobtainable through pulsed extraction and ion optics alone.

MS/MS fragmentation in the MALDI-7090 is true high-energy CID (HE-CID).

Ions enter the collision cell at 20keV extraction energy. Furthermore, collisions with helium rather than heavier gases (air or argon) result in the most efficient generation of ions only associated with HE-CID (e.g.: peptide side –chain and lipid backbone fragmentation).

MS/MS fragmentation is further enriched by retaining all of the metastable decay ions through the reflectron analyzer, maximizing the amount of information extracted from each sample.

The MALDI-7090 can also be used in low-energy fragmentation mode without collision gas. Here the fragmentation relies on spontaneous metastable decay of the precursor and exhibits low-energy type ions.